4-HO-MiPT Fumarate

This substance is relatively uncommon and has only a short history of human use. Alexander Shulgin evaluated its activity in humans in 1979, describing a trial of 12mg as a richly insightful and highly erotic experience. A description of 4-HO-MiPT is included in Shulgin’s 1997 book TiHKAL. Shulgin’s trials and other anecdotal reports suggest that 4-HO-MiPT is similar in activity to psilocin, the active component in psilocybin mushrooms.

Chemical Properties of 4-HO-MiPT

4-HO-MiPT is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-MiPT is substituted at R4 of its indole heterocycle with a hydroxyl (HO) functional group OH-. It also contains a methyl group and an isopropyl chain bound to the terminal amine RN of its tryptamine backbone (MiPT). 4-HO-MiPT is the N-substituted isopropyl homologue of 4-HO-DMT (Psilocin)

What are the Effects of 4-HO-MiPT?

4-HO-MiPT’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

4-HO-MiPT has many overlapping effects with substances like 1P-LSD and 4-HO-MET.

Some of the most commonly reported effects of 4-HO-MiPT are: 

•     Stimulation
•     Spontaneous bodily sensations
•     Physical euphoria
•     Visual hallucinations
•     Increased music appreciation
•     Colour enhancement
•     Emotion enhancement
•     Cognitive euphoria

Potential Side Effects of 4-HO-MiPT

•     Nausea
•     Muscle contractions
•     Thought loops
•     Feelings of impending doom
•     Increased salivation
•     Delusion
•     Pupil dilation